1. The First Minutes After a Traumatic Brain Injury
Within seconds of a traumatic brain injury (TBI), a destructive cascade begins inside the brain’s cells:
- Oxygen level drops inside brain cells (hypoxia)
- Mitochondria shut down, producing massive oxidative stress
- Free radicals spike, damaging membranes and DNA
- Intracellular glutathione (GSH) — the key antioxidant — is instantly depleted
This sets off a self-perpetuating cycle of inflammation, swelling, and neuronal death that continues for hours and days after impact.
2. ProImmune’s All-Natural Safe Mechanism — Intracellular Protection
ProImmune – Immune Formulation 200 works at the root cause of cellular injury by enabling cells to immediately synthesize glutathione (GSH) inside the cell. That means:
- Neutralizes oxidative radicals as they form
- Stabilizes mitochondria before they collapse
- Restores intracellular oxygen handling naturally
- Stops lipid peroxidation and inflammatory signaling at the molecular level
- Activates the Nrf2 gene to trigger cells to replenish glutathione immediately at the site of traumatic incidence
In short, it prevents secondary brain injury at the biochemical origin: the oxidative cascade.
3. HBOT’s Mechanism — Oxygenation from Outside
Hyperbaric Oxygen Therapy (HBOT) increases extracellular oxygen availability by delivering oxygen under pressure, which dissolves more O2 into plasma and can reach hypoxic tissues. This helps:
- Reduce brain swelling and hypoxia
- Support tissue repair and angiogenesis
- Enhance mitochondrial ATP production
However, HBOT does not correct intracellular antioxidant depletion (glutathione loss) — so while it improves oxygen delivery, it can actually increase oxidative stress if glutathione levels remain low. Dr. Albert B. Crum, M.D., DSc (Hon), M.S., teaches that ProImmune supplementation mitigates the waste byproducts caused by increases of oxygen.
4. Comparison at Onset of TBI
| Action | ProImmune (IF200) | HBOT |
|---|---|---|
| Timing | Immediate oral or IV dosing can begin within minutes | Requires transport and chamber setup |
| Mechanism | Restores intracellular glutathione and halts oxidative stress | Increases tissue oxygen saturation |
| Primary Benefit | Stops oxidative damage from inside the cell | Improves oxygenation from outside the cell |
| Limitation | Needs intracellular synthesis (minutes) | Does not address glutathione depletion |
| Ideal Use | Acute antioxidant defense and stabilization | Secondary recovery and tissue regeneration |
5. Optimal Strategy
The most protective strategy appears to be administering ProImmune immediately, followed by HBOT as soon as practical.
- ProImmune first halts the oxidative cascade and stabilizes cell membranes.
- HBOT second then safely floods the tissue with oxygen once the antioxidant defenses are restored — preventing oxygen toxicity and amplifying cellular recovery.
ProImmune prepares the cells to handle oxygen. HBOT supplies the oxygen for deeper healing.
Summary
- ProImmune at onset: Stops oxidative destruction by restoring intracellular glutathione and cellular oxygen balance.
- HBOT later: Enhances perfusion and tissue recovery once antioxidant defenses are reestablished.
If you can only do one immediately at the point of injury — ProImmune offers the faster intracellular protection. If you can do both sequentially — you create a synergistic, dual-protection model that addresses both oxidative stress and oxygen deficiency.
A Message From Dr. Albert B. Crum About Waste Byproducts with HBOT
Dr. Albert B. Crum, M.D., DSc (Hon), M.S.
ProImmune® has been on the market globally since 2008 and provides certain advantages that can support your hyperbaric treatment projects. This discovery entails using ProImmune’s® Free Form Amino Acid Precursors™ (FFAAP™). This product does not require catabolism before it is utilizable in the synthesis of glutathione. As you well understand, oxygen therapy increases cellular metabolism and thus produces waste products via oxidative stress. That is where the unity of restoration purpose with glutathione — especially the precursors to glutathione, known as ProImmune® – Immune Formulation 200® — is so helpful with HBOT.
The glutathione remediates the oxidative stress and scavenges the waste products by neutralizing the open valences in the process that are caused by the heightened metabolism of oxidative stress. Those open valences are a necessary consequence of oxygen therapy with its increase in metabolism. This is where the efficiency of the FFAAP™ product can be very helpful and useful in the restoration process. Incorporating ProImmune® could optimize health to unprecedented levels by incorporating ProImmune®’s FFAAP™ product, which is also known as Immune Formulation 200®, before and after HBOT.
The method of action would simply be to deposit one regular scoop of Immune Formulation 200® on the patient’s tongue — almost immediately the Free Form Amino Acid Precursors™ enter the bloodstream and into the cellular synthesis of glutathione. A scooper is included in each jar.
— Albert B. Crum, M.D., DSc (Hon), M.S., Harvard Medical School Graduate
Contact: Joseph V. Cassarino at TheBestImmuneSupport.com · info@TheBestImmuneSupport.com · Instagram: Best Immune Support · Cell or Text: 845-206-8104
The opinions and content of this article are the opinions of Joseph V. Cassarino, distributor for ProImmune, and are not intended as medical advice and are not intended to treat, cure or prevent any illness. Always check with your medical provider before starting any new health regime.