The Science Behind ProImmune

Dr. Albert B. Crum's Discovery

With Dr. Crum's extensive background in chemistry as an undergraduate and later at the Harvard Medical School, he was intrigued by what was observed clinically and what was going on in the body biochemically. He realized that glutathione was a pivotal molecule in the preservation and restoration of the immune system.

He felt the approach should be to find a way of restoring the glutathione molecule intracellularly — allowing the cell to carry out its natural function for which it had been evolved and perfected, namely synthesis of the glutathione molecule with specific enzymes.

Dr. Crum felt that with the rapid turnover of glutathione, the most important way to achieve the physiological goal would be to facilitate and augment intracellular synthesis, which mechanism had already been highly perfected by years of evolution.

The Intracellular Approach

Intracellular synthesis presented crucial and highly sensitive problems, because the most crucial entity cysteine could not be delivered into the cell per se. Dr. Crum's invention foresaw cystine as being the primary systemic carrier of cysteine, hence this coupling's being the reason why cystine could function as the primary carrier of cysteine.

Dr. Crum's patent is also an economic avenue for replenishment of bodily glutathione.*

The term FFAAP the GSU research refers to is a trademark of The ProImmune Co. LLC.

The Science of Glutathione

Oxidative stress, toxicity and chronic inflammation are the root causes of many ailments. Just one serving up to twice per day of the semi-sweet tasting Immune Formulation 200® powder daily can help the body naturally lower oxidative stress and support the immune system.*

One jar contains more than 60 servings and can last one to two months, per adult. With sales for over ten years, and with proof of concept, Immune Formulation 200® helps maintain glutathione levels in a manner that helps every cell, tissue and organ function optimally.*

Immune Formulation 200® is natural to the human body and contains only ingredients your cells need to create intracellular glutathione, the body's Master Antioxidant.* Proudly made in the U.S.A., with globally sourced components in an FDA good manufacturing practices registered and compliant facility.

Other Ingredients: Dicalcium Phosphate — Only a minuscule amount of 0.001% of Dicalcium Phosphate is added and is ultra safe in this minimal amount.

NSF-GMP Certified Facility

ProImmune is manufactured in compliance with NSF-GMP (Good Manufacturing Practices) standards. GMP is a comprehensive framework of processes, procedures, and documentation designed to maintain strict control over manufacturing, ensuring product safety and consistent quality. The GMP standards outlined under NSF/ANSI 455 were established in alignment with the requirements of the American National Standards Institute (ANSI).

NSF provides independent certification to manufacturers that meet these GMP standards. This program is available to producers and packagers of dietary supplements, cosmetics, and over-the-counter medications who aim to demonstrate a strong commitment to consumer safety. Certification from a globally recognized public health organization reflects adherence to U.S. GMP regulations and dedication to high-quality supplement production.

Thorough In-House and Third-Party Testing

Every batch we manufacture is subjected to comprehensive testing, both internally and through independent third-party laboratories. This ensures that each product consistently meets our strict standards for safety, quality, and potency.

ProImmune has been peer reviewed by 18 universities under an $88M NIH research grant confirming ProImmune as the most effective and efficient intracellular glutathione synthesis over synthetic glutathione or NAC.

As Featured in Scientific American Magazine

Scientific American — May 2026

“Chronic inflammation — a prolonged and body-damaging state of immune system activation — may be the hidden factor that accelerates cardiovascular problems to a dangerous and deadly” state.

Heart disease is “a disease of inflammation,” says Kathryn Moore, director of the Cardiovascular Research Center at New York University’s Grossman School of Medicine.

“ProImmune, an all-natural intracellular glutathione precursor, has been proven to reduce oxidative stress more effectively and efficiently than any form of synthetic glutathione or NAC, as demonstrated in research conducted under an $88M NIH grant across 18 universities. ProImmune reduces oxidative stress and inflammation directly inside cells at the cellular level, aligned with nature’s principles of evolution. Supplementing with ProImmune to reduce oxidative stress and inflammation at the cellular level may increase life expectancy and provide your cells and heart with the ability to thrive.”

— Joseph V. Cassarino, Founder, BestImmuneSupport.com, and Representative for Dr. Albert B. Crum, M.D., DSc (Hon), M.S.

Have your physician check your C-reactive protein (CRP), a molecular marker signaling inflammation, as well as your cholesterol levels. After completing these tests, take ProImmune twice daily (AM & PM) for three consecutive months. Then, recheck your C-reactive protein and cholesterol levels. ProImmune has been approved in 37 countries as an all-natural statin to help modulate cholesterol, triglycerides, and A1C to optimal ranges.*